OS according to therapy arms and renal function. (A) OS in the VMPT-VT and VMP arms in patients with normal renal function (eGFR ≥ 50 mL/min) or RI (eGFR < 50 mL/min). (B) OS in the VMPT-VT and VMP arms in patients with moderate RI (eGFR 31-50 mL/min) and severe RI (eGFR < 30 mL/min).