Notch signaling in the interactions between B-ALL cells and mesenchymal stromal cells. Interaction of Notch receptors and ligands expressed by bone marrow mesenchymal stromal cells (MSC), obtained from normal individuals and patients, and their counterparts expressed by B-ALL cells leads to the survival increase of leukemia cells and enhanced resistance to chemotherapeutical agents. Receptors and ligands written in bold mean strong expression, written in italics mean absent or weak expression. Jagged 1, Jagged 2, and DLL 1 bind to all the Notch receptors; DLL 3 binds to Notch 1; DLL 4 binds to Notch 1 and Notch 4. *Notch molecules involved in the antiapoptotic effects.²⁹  For references, see text.