Susceptibility to DSS-induced colitis. (A) Colonoscopy scores of WT mice, CX₃CR1^−/− mice, CX₃CL1^−/− mice, CX₃CL1^395AA:CX₃CL1^−/− mice, and CX₃CL1^105Δ:CX₃CL1^−/− mice after indicated DSS challenge (day 7). (B) Representative colonoscopy images taken from mice at day 7. (C) Change of colonoscopy scores between day 7 and day 10. (D) ELISA of serum of WT mice, CX₃CR1^−/− mice, CX₃CL1^−/− mice, CX₃CL1^395AA:CX₃CL1^−/− mice, and CX₃CL1^105Δ:CX₃CL1^−/− mice after indicated DSS challenge for IL-6 (day 10). Results are one representative of 2 independent experiments (N = 5-7). *P < .05 (1-way ANOVA followed by Bonferroni Multiple Comparison). ***P < .001 (1-way ANOVA followed by Bonferroni Multiple Comparison).