Cytokine production profile and lytic activities of Mucorales-specific T cells. (A-B) The frequencies of Mucorales-specific T cells producing IFNγ, IL-10, IL-4, or IL-17, either as EM (light gray) or CM (dark gray), are shown as the mean percentage of positive cells, computed for the 3 patients with IM. Results are expressed as percentages of either CD4⁺ T cells (A) or CD8⁺ T cells (B). Mean frequencies of specific cytokine-producing T cells for individual patients are reported in each column, either as EM (■) or CM (○). (C-D) Hyphal damage at 2 (C) and 22 (D) hours to Rhizomucor pusillus and Rhizopus oryzae hyphae induced by anti-Mucorales T cells (T), polymorphonuclear leukocytes (PMNs), and antigen-presenting cells (APCs), alone or in combination, derived from patients 1 and 2 during the course of IM. E:T indicates effector/target cell ratio.