Neurologic phenotype in CMV-λ6 mice. (A) The transgenic mice displayed less spontaneous activity compared with wild-type controls when fasted overnight (P < .018 horizontal, P < .0068 vertical, n = 4 each group). (B) Exercise capacity on an inclined treadmill was diminished in older transgenic mice compared with age-matched controls (P < .011, n = 4 each group). (C) H&E-stained section of spinal cord revealing dystrophic neurons (example denoted as *) in an old transgenic mouse with the limb clenching phenotype.