Dynamics of short-term imatinib mesylate treatment response. The figure displays the kinetics of the leukemic cell burden in patients treated with imatinib mesylate for 1 year after diagnosis in early chronic phase. (A-D) The panels show the percentage of cancer cells (BCR-ABL1/BCR as measured by RQ-PCR) of 4 individual patients with CML (circles) and the fitted biphasic exponential model (red curves). This fitted model shows that there is a biphasic exponential depletion of leukemic cells within the first year of treatment. (E) The panel displays the median (orange circles) and quartiles of the short-term imatinib mesylate response data together with the fitted biphasic exponential model (red curve). See supplemental Figure 1 for all patient plots and model fitting.