gp120 V2 and V3 loops mediate binding to Vγ2Vδ2 cells. (A-B) Fluorescein-conjugated HIV gp120/YU2 (A) or CN54 gp120 (B) was pre-incubated with specific antibodies against (20 μg/mL) for 30 minutes at room temperature, and then the mixtures were added to Vγ2Vδ2 T cells for staining (A) or cell killing assays (B). Inhibition of binding or cell death was calculated in relation to gp120 killing or binding is relative to gp120 in the absence of added antibodies. Data are representative of 3 independent experiments (error bars, SD).