Engraftment, migration to cranium, and overall disease burden after transplantation with SD1 is decreased by the concomitant administration of RACi or microRNA silencing of RAC2 (RAC2^kd). (A) Bioluminescence signal intensity measured as photons/cm²/s in mice transplanted with SD1 cells with or without RACi. Horizontal lines denote mean intensity. (B) Survival of mice engrafted with SD1 was significantly improved with the concomitant administration of the RACi (left panel) as was the survival of SD1^RAC2kd engrafted mice (right panel).