Influence of the degree of donor cell engraftment on the reconstitution of lymphocyte counts and autoimmunity after HCT. Data are shown for WAS-transplanted patients who had at least 12 months of follow-up after HCT and for whom data of lineage-specific chimerism were available. (A) The percentage of donor chimerism for each cell lineage at the time of last follow-up is shown for patients who attained (Y) or did not attain (N) normalization of T- and B-cell counts (defined as CD3⁺ > 1000 cells/μL, CD4⁺ > 600 cells/μL, CD8⁺ > 300 cells/μL, and CD19⁺ > 200 cells/μL). **P < .01. (B) The percentage of donor lineage-specific chimerism is shown for patients who developed (Y) or did not develop (N) autoimmunity. *P < .05. **P < .01. Horizontal bars represent mean values (A-B).