Innate T cells are autoreactive. (A-B) Reactivity of WT TCRVδ6⁺, TCRVδ6⁻ γδT, and αβNKT-cell–derived hybridomas. (C-D) Reactivity of αβNKT-cell–derived hybridomas from WT and CD1d^−/−TCRδ^−/− mice. (A,C) Cumulative fraction of hybridomas for which the response exceeded the level indicated on the x-axis. (B,D) Percentage of autoreactive hybridomas determined as percentage of hybridomas for which the response exceeded 1% of maximum. Dark bars represent reactivity toward autologous thymocytes; light bars spontaneous reactivity. P values of χ tests are shown.