Biodistribution of free ALX-0081 and ALX-0081 complexed with human VWF in mice. Radioactivity (as percentage of total) found in blood (○, solid lines), kidney (□, dashed lines), and liver (▵, dotted lines) on injection of ¹²⁵I-radiolabeled ALX-0081 free (A) or in complex with human VWF (B). Results are expressed as mean ± SD, n = 3 for each time point.