Cre;Sclfl/fl mice are thrombocytopenic. Peripheral blood parameters were analyzed in mice over an 8-month period. (♦) represents Cre;Sclwt/wt mice; and , Cre;Sclfl/fl mice. Each diamond or dot represents an individual mouse. Horizontal bars represent the mean. Platelets, P = 1.8 × 10−12; MPV, mean platelet volume, P = 1.2 × 10−5; WBC, white blood cells, P = 3.7 × 10−5; RBC, red blood cells, P > .1; and HCT, hematocrit, P > .1. For each time point, the analysis was performed on 5 to 8 Cre;Sclfl/fl mice or 3 to 11 Cre;Sclwt/wt mice.