Unsupervised complete linkage hierarchical clustering of samples according to methylation of the 2764 differentially methylated CpG sites. There are 2 outliers and 6 major clusters of samples. The normal samples clustered together within cluster one (gray) and are marked by gray boxes below the dendrogram. Mutational status is indicated below; white boxes represent wild-type; and colored boxes, mutations. P values are given for unequal distribution between clusters for each mutation using the Fisher-Freeman-Halton test (outliers were disregarded). The frequency of NPM1 mutations is increased in cluster 2 and 6, IDH1 in cluster 6, and IDH2 in cluster 2.