Macroscopic liver injury and microscopic histology of lung tissue: representative samples. Postmortem internal organs were removed to evaluate the degree of liver injury and to assess the occurrence of any thromboembolic events. (A-B) Macroscopic and histologic images of liver trauma, with laceration of venous vessels up to 4 mm in diameter. (B) H&E stain. (C-E) Multiple thromboemboli in the PCC50 group (up to 4 mm in panel E). (C,E) H&E stain. (D) Immunohistochemical staining against fibrinogen. (F-G) Samples from the control group and PCC50 without DIC with rare, irregular, small deposits of fibrinogen in lung capillaries. (H) Net-like staining pattern for fibrinogen in lung capillaries of animals of the PCC50 group wth DIC. (F-H) Immunohistochemical stain against fibrinogen. Original magnification: panels B and E, 20×; panels C-D, 40×; panels F-H, 400×.