Relationship between BMI, on a continuous scale, and the hazard of relapse. The relationship is modeled by a restricted cubic spline model (bold line). Model-based 95% CIs are also reported (dashed lines). The median BMI value (25.8) was considered as the reference in the estimation of the hazard ratio. Estimates were adjusted for sex and age in a Cox proportional hazard model. The rug plots placed at the top and bottom of the graph show the BMI values in patients that relapsed (top) and in those who did not relapse (bottom).