Mevalonate restores the capacity of 12/15-Lox^−/− mice to respond to hind-limb ischemia in the induction of Rac1 farnesylation and activation and new blood vessel formation. (A) Tissue extracts were prepared from ischemic and non-ischemic adductor muscles of 12/15-Lox^−/− mice that were administered with and without mevalonate and analyzed for Rac1 farnesylation and activation as described in Figure 3. (B) Blood perfusion was measured by LDPI. The bar graphs represent the mean ± SD values of 3 independent experiments or 6 animals. *P < .05 versus ischemia.