Risks of developing major heart AL amyloidosis according to the involved Ig LC germline gene adjusted for potential confounders (see “Family and germline gene use”) in multivariable logistic model.IGVL1-44 was the only germline gene to be associated with heart involvement, as shown by the OR > 1 and the 95% CI whisker not crossing the no-effect line (OR = 1). Conversely, IGVL6-57 expression was against major heart involvement, being this gene associated with kidney involvement.