Based on the work of Narla et al,1 the sites of action of corticosteroids and lenalidomide in promoting erythropoiesis from CD34+ cells are shown. Similar sites of action are observed for normal CD34+ cells and CD34+ cells haploinsufficient for ribosomal protein Rps19 or Rps14 (RP haploinsufficiency). Blue labels are given for existing therapies, red labels are provided for potential combination therapies. Professional illustration by Kenneth X. Probst.
