CXCL10 induces MMP9 expression and activity in BCP-ALL cells. (A) Representative zymography assay showing MMP9 activity in the supernatants of a panel of BCP-ALL cells treated with recombinant human CXCL10. (B) MMP9 gene expression in the indicated BCP-ALL cells after treatment with recombinant human CXCL10. Data are mean ± SEM (n = 3). *P < .05 with respect to untreated (0 ng/mL). (C) Correlation analysis of CXCL10 and MMP9 gene expression in human B-cell ALL patients. Correlation studies were performed on publicly available gene expression datasets of 3 cohorts of human B-cell ALL patients. Data normalization and correlation analysis are described in “Data analysis for correlation studies.”