Figure 5
Figure 5. Working hypothesis of IL24 on MLL/AF4-positive ALL. IL24 induces MLL/AF4-positive ALL to caspase 8–caspase 3 apoptotic pathways through down-regulation of HOXA9 and S100A6 followed by p53 acetylation and it also induces apoptosis through ER stress pathway and antiangiogenesis.

Working hypothesis of IL24 on MLL/AF4-positive ALL. IL24 induces MLL/AF4-positive ALL to caspase 8–caspase 3 apoptotic pathways through down-regulation of HOXA9 and S100A6 followed by p53 acetylation and it also induces apoptosis through ER stress pathway and antiangiogenesis.

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