Sensitivity of primary ALL cells to survivin-targeting EZN-3042. (A-G) Dose sensitivity of primary ALL cells to single-agent survivin antisense EZN-3042 and scrambled control EZN-3088 was determined. ALL cells were cocultured with OP9 cells and treated for 7 days with single-agent doses ranging from 5-20μM of respective LNA. Cell viability was determined by Trypan blue exclusion of dead cells.