Group mean plasma FVIII activity PK profiles for low-dose and high-dose cohorts. The plasma FVIII activity (one-stage aPTT assay) versus time curve after a single intravenous injection of rFVIIIFc or rFVIII are shown for (A) 25 IU/kg (low-dose cohort; n = 6) and (B) 65 IU/kg (high-dose cohort; n = 10 [rFVIII]; n = 9, [rFVIIIFc]). Results presented are group mean ± SEM.