Effect of VWF Ag levels on CL and t_1/2 of FVIII activity after injection of rFVIII or rFVIIIFc. Correlation between VWF Ag levels and (A) the weight-adjusted CL of rFVIII (R² = 0.5415, P = .0012) and rFVIIIFc (R² = 0.5492, P = .0016) and (B) the t_1/2 of rFVIII (R² = 0.7923, P < .0001) and rFVIIIFc (R² = 0.6403, P = .0003). Each dot represents an individual subject.