Change in PCA at various times after incubation of target APL cells with phagocytes. A total of 1 × 10⁶ target APL cells were incubated with 5 × 10⁵ THP-1–derived MΦs and HUVECs separately in 12-well culture plates for indicated times. Target APL cells were used as control. In a time-dependent manner, clotting time of the mixed cells increased (A), whereas generation of intrinsic FXa (B), extrinsic FXa (C), or thrombin (D) decreased. *P < .05 compared with 0 hour time point of each group.