Improved prophylactic efficacy of rFVIIIFc relative to rFVIII in the TVT bleeding model. Male HemA mice were injured by TVT either 24 hours following vehicle, or rFVIII, or rFVIIIFc treatment, or 48 hours following rFVIIIFc treatment. The survival and rebleed within 24 hours following TVT are shown in panels A and B, respectively. (A) *P<.001 by log-rank test of the survival curves from animals that received 12 IU/kg rFVIIIFc vs rFVIII 24 hours before TVT. (B) ^#P = .002 by log-rank test of the non-rebleed curves from animals that received 12 IU/kg rFVIIIFc vs rFVIII 24 hours before TVT.