p16^INK4a deficiency results in an alteration of STAT1 and NF-κB signaling. Representation of the relative microarray intensity values from a selection of down-regulated genes in p16^+/+ and p16^−/− BMDM with or without polarization (AAMφ) by 15 ng/mL IL-4 from day 0 of differentiation. Statistically significant differences are indicated (a: P < .05 compared with p16^+/+ BMDM; b: P < .05 compared with p16^−/− BMDM; c: P < .05 compared with p16^+/+ AAMφ).