Deletions of 7q36.1 involving MLL3. (A) Log2 ratio SNP copy number data in 23 cases at diagnosis with focal or more extensive deletions (P indicates paired normal; and D, diagnosis). (B) Minimally deleted region in 7q36.1 (647 Kb in size) defined by case i16245 containing the 4 genes PRKAG2, GALNTL5, GALNTL11, and MLL3. Each vertical red line represents the genomic position and log2 ratio copy number of an individual marker. (C) Sequencing of MLL3 showing a truncating mutation leading to a premature stop codon in a single case (AE201) without del(7q).