Dose-response relationship for reduction of liver FXI mRNA and systemic FXI activity and elevation of APTT following 13 weeks of ISIS 416858 treatment. Cynomologus monkeys were administered ISIS 416858 (0, 4, 8, 12, 40 mg/kg/wk, SC) for up to 13 weeks. Liver tissue for FXI mRNA levels and blood for assessment of FXI activity and APTT were harvested at the 13-week time point. Data represents mean ± SD.