D1- and P4-specific CD8 T cells recognize primary MM tissue from HLA-A2–positive patients. Sorted D1- or P4-positive CD8 T cells were tested by ELISpot against MM BMMCs isolated from fresh BM from HLA-A2–positive donors. D1-specific (A) and P4-specific (B) T cells recognized primary MM BMMCs from HLA-A2–positive donors (n = 5), but not healthy HLA-A2–positive BMMCs (n = 2) or HLA-A2–negative MM BMMCs (n = 4).