PN-1 is antithrombotic and antifibrinolytic. (A) Time to occlusion of mesenteric venules measured after application of 15% FeCl₃ in wild-type and PN-1–deficient mice. ***P < .001 (linear mixed-effects model) versus wild type. (B) Quantification of the incidence of recanalyzed vessels within 1 hour after tPA treatment after an occlusion induced by 15% FeCl₃. The incidence of recanalization was 15% in wild-type mice (2 of 13 vessels) and 92% in PN-1–deficient mice (12 of 13 vessels).