Rantes KO mice have less myeloid progenitors and less myeloid-biased stem cells. (A) CBC analyses of 5- to 6-month-old WT and Rantes KO mice. Graphical representation of CBC analysis of WT or KO mice. (B) BM frequencies of myeloid progenitors (CMP, GMP, MEP) from 5- to 6-month-old WT and KO mice. (C) BM derived from WT or Rantes KO mice was isolated and analyzed for Ly- and My-bi HSCs as follows: KLS cells were identified, followed by the CD150⁺ fraction, followed by analysis of lower and upper SP phenotypes. Representative FACS profiles of lower and upper SP^KLS-CD150+ HSCs from WT and Rantes KO mice. (D) Frequencies of lower and upper SP^KLS-CD150+ cells from WT and KO mice. (E) BM frequencies of stem and progenitor populations: KSL, SP^KLS from 5- to 6-month-old WT and KO mice. n = 5 WT, n = 5 KO in (A-D). Error bars represent SEM. Representative of 2 experiments