ArhGAP15-null mice are protected against CLP-induced severe sepsis. (A) Number of neutrophils recruited to the peritoneal cavity after CLP; n = 7/genotype. (B) Bacterial load of peritoneal lavage; n = 7/genotype. (C) Bacterial load of isolated spleens; n = 7/genotype. (D) Serum cytokine concentrations 6 hours after CLP; n = 7/genotype. (E) Kaplan-Meier survival analysis of ArhGAP15^+/+ and ArhGAP15^−/− mice after CLP-induced sepsis; n = 7/genotype. #P < .05. *P < .01.