Activation of bronchoalveolar coagulation in asthma with interventions examined in the murine ovalbumin allergic lung inflammation model. Plasma (containing clotting factors, such as FVII and FX) leaks from lung capillaries as a consequence of the inflammatory response. TF expression on epithelial cells, eosinophils, and macrophages initiates intra-alveolar coagulation by activation of FVII (which can also be produced by epithelial cells). Interventions with the anticoagulants fondaparinux (FXa inhibitor) and hirudin (thrombin inhibitor) and the plasminogen activators tPA and uPA improve the disturbed pulmonary hemostatic balance and concurrently diminish allergic inflammation and asthma parameters in experimental settings.