Patients receiving infusions of anti–CD19-CAR–transduced T cells had reductions in adenopathy and elimination of normal B cells. CT scans of patient 7 showed extensive adenopathy before treatment. This adenopathy regressed by day 32 after CAR-transduced T-cell infusion (arrow). The enlarged lymph nodes continued to substantially regress between 32 and 132 days after CAR-transduced T-cell infusion. (B) Patient 8 had a normal number of polyclonal blood B cells before treatment. B cells were eliminated from the blood after treatment and had not recovered 26 weeks after anti–CD19-CAR–transduced T-cell infusion. B cell counts were determined by flow cytometry for CD19 and confirmed by flow cytometry for CD20. In contrast to the B cells, blood T-cell counts (C) and NK-cell counts (D) rapidly recovered after treatment.