CD57 is preferentially acquired on NKG2C+ cells in the first year after CMV reactivation. CD57 co-expression was measured on NKG2C+ (○) and NKG2C− (■) NK cells from recipients without CMV infection (top panel) and with CMV infection (bottom panel). The ratio of CD57+/CD57− was plotted at the indicated time points. Points represent the means ± SEM. The slope of time for NKG2C+ NK cells was compared between recipients who reactivated CMV and those who did not using a linear mixed model, P = .0015.