Platelet surface markers of activation in controls following in vitro manipulation of platelet counts. (A) Activated GPIIb/IIIa, (B) P-selectin, and (C) GPIb. Data are mean ± SEM, n = 5 (*P < .05, **P < .02) for agonist-induced platelet integrin expression in thrombocytopenic samples compared with that at “normal” platelet counts (ie, 175 × 109/L).