Model of the effect of panobinostat (LBH589) and everolimus (RAD001) on the PI3K/AKT/mTOR pathway. This model shows the complementary inhibition of panobinostat and everolimus on the PI3K/AKT/mTOR pathway. LBH589 inhibits the AKT activation induced by RAD001, whereas RAD001 inhibits the mTOR activation induced by LBH589.