Targeted activation of PTH1R in osteocytes increases osteoblastic cells and trabecular bone. (A) Schematic representation of the transgene construct. (B) Expression of the transgene in tibia and lumbar spine of mice at 3.5 weeks of age. (C-D) H&E staining of longitudinal sections of representative distal femora from 3.5-week-old WT (C,E) and TG (D,F) littermate mice. Bars indicate 0.2 mm (C-D) and 0.05 mm (E-F). *P < .001. (C) Representative longitudinal and cross-sectional micro-CT images of distal femora from 4-week-old WT and TG littermate mice. Table insert includes quantification of micro-CT parameters (mean ± SD) from 3 female and 1 male mice in each group, age 3.5 weeks. *P ≤ .05