Normal B cell development in Dok-3^−/− mice. Flow cytometry analyses of B cell populations in the bone marrow (A and B), spleen (C), lymph nodes (D) and peritoneal cavity (E) of wild-type and Dok-3^−/− mice. Bone marrow B220 ⁺IgM⁻ cells were further analyzed for their expression of CD43, CD2, CD25 and BP-1 (B). Numbers indicate percent of cells in the lymphocyte gate for (A, C, D and E) and percent of B220 ⁺IgM⁻ cells for (B). Data shown are representative of 3 independent experiments.