PCA on samples without BCR activation distinguishes M-CLL and UM-CLL cells. PCA as a score plot of a spot map of the 24 US samples (12 M-CLL and 12 UM-CLL) color-coded according to the legend, projected onto the first 2 principal components. PC1 axis segregated most M-CLL and UM-CLL samples; #M3 patient samples colored in blue provided from M-responder-CLL (Mr) cells and segregated like UM-CLL samples. The oval englobes a 95% statistical confidence perimeter.