Figure 7
Figure 7. Immunodominant T-cell epitopes of human FVIII identified in E17 HLA-DRB1*1501 mice bind to a variety of different HLA-DRB1* haplotypes. (A) The binding of dominant T-cell epitopes of FVIII, as identified in E17 HLA-DRB1*1501 mice to the 6 most common HLA-DRB1* haplotypes, was analyzed using the REVEAL class II technology of ProImmune, as described in “Binding of peptides to HLA-DRB1* haplotypes.” The Cumulative Pan-Allele ProImmune REVEAL score for each peptide across all of the 6 HLA-DRB1* haplotypes was calculated by adding up the ProImmune REVEAL scores of each of the 6 HLA-DRB1* haplotypes analyzed divided by 6. For illustration, different colors corresponding to the contribution of each of the different HLA-DRB1* haplotypes tested were used. (B) The kinetics score for binding of the dominant T-cell epitopes of FVIII to the 6 most common HLA-DRB1* haplotypes was determined using the full rate assay technology of ProImmune, as described in “Binding of peptides to HLA-DRB1* haplotypes.” The Cumulative Pan-Allele kinetics score for each peptide across all of the 6 HLA-DRB1* haplotypes was calculated by adding up the kinetics scores of each of the 6 HLA-DRB1* haplotypes analyzed divided by 6. Different colors corresponding to the contribution of each of the different HLA-DRB1* haplotypes tested were used for illustration.

Immunodominant T-cell epitopes of human FVIII identified in E17 HLA-DRB1*1501 mice bind to a variety of different HLA-DRB1* haplotypes. (A) The binding of dominant T-cell epitopes of FVIII, as identified in E17 HLA-DRB1*1501 mice to the 6 most common HLA-DRB1* haplotypes, was analyzed using the REVEAL class II technology of ProImmune, as described in “Binding of peptides to HLA-DRB1* haplotypes.” The Cumulative Pan-Allele ProImmune REVEAL score for each peptide across all of the 6 HLA-DRB1* haplotypes was calculated by adding up the ProImmune REVEAL scores of each of the 6 HLA-DRB1* haplotypes analyzed divided by 6. For illustration, different colors corresponding to the contribution of each of the different HLA-DRB1* haplotypes tested were used. (B) The kinetics score for binding of the dominant T-cell epitopes of FVIII to the 6 most common HLA-DRB1* haplotypes was determined using the full rate assay technology of ProImmune, as described in “Binding of peptides to HLA-DRB1* haplotypes.” The Cumulative Pan-Allele kinetics score for each peptide across all of the 6 HLA-DRB1* haplotypes was calculated by adding up the kinetics scores of each of the 6 HLA-DRB1* haplotypes analyzed divided by 6. Different colors corresponding to the contribution of each of the different HLA-DRB1* haplotypes tested were used for illustration.

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