Probability of IRIS onset according to total NK-cell degranulation capacity before cART initiation. The association between total NK-cell activity before cART initiation and the occurrence of TB-IRIS is shown using Kaplan-Meier curves. Each factor was subdivided into 4 categories based on the 25th, 50th, and 75th percentiles. Plain line ≤ 1st quartile; dashed line, 1st quartile to median; dotted line, median to 3rd quartile; and dashed-dotted line > 3rd quartile (P = .002 by log-rank test).