Figure 2
Figure 2. Impaired cell-cell contact of Eμ-TCL1Tg;Rhoh−/−CLL and NLCs. (A-B) show colocalization of murine NLCs with CLL cells (arrowheads) in representative bright-field photomicrographs of WT and Rhoh−/− (A) spleen cells and (B) PBMNCs of Eμ-TCL1Tg animals at 200× magnification (n = 2-4). The table for each panel indicates number of CLL cells colocalized per NLC enumerated in 2 randomly selected microscopic fields at 200× magnification (WT versus Rhoh−/−; mean ± SEM, **P = .0001 and *P = .001, Student t test).

Impaired cell-cell contact of Eμ-TCL1Tg;Rhoh−/−CLL and NLCs. (A-B) show colocalization of murine NLCs with CLL cells (arrowheads) in representative bright-field photomicrographs of WT and Rhoh−/− (A) spleen cells and (B) PBMNCs of Eμ-TCL1Tg animals at 200× magnification (n = 2-4). The table for each panel indicates number of CLL cells colocalized per NLC enumerated in 2 randomly selected microscopic fields at 200× magnification (WT versus Rhoh−/−; mean ± SEM, **P = .0001 and *P = .001, Student t test).

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