There are significant associations between CIS-associated candidate genes and disease phenotypes, experimental cohorts, and other CIS-associated candidate genes. Modified heat map of significant candidate gene and phenotype enrichment in (A) WT and (B) Mll-AF9 mice. Each horizontal tick mark represents a proviral insertion identifying a CIS or a positive marker for a given phenotype in a given mouse leukemia. Mice are divided into the 2 infected genotypes across the x-axis; significant phenotypes and candidate genes are along the y-axis. Positive significant associations of phenotypes and candidate genes are shown (P < .05). In addition, candidate genes are shown that were found in 4 separate animals only in Mll-AF9 leukemias (P = .08). (C) Network of significant associations between phenotypes, genotypes, and candidate genes. All associations with P values < .05 were used. Genotypes are shown in squares, phenotypes are shown in diamonds, and CIS-associated candidate genes are shown in circles.