Human GEP and gene copy number data for candidate Mll-AF9 cooperating genes. (A) Dot plots of expression of 2 CIS-associated candidate gene homologs in AML patients: FOSB and BCL11A. A representative probe for BCL11A is shown. Total BM (TBM) and CD34⁺ cells from healthy patients (n = 5 and 14, respectively) were used as controls compared with AMLs with any MLL rearrangement (n = 11), and patients with MLL-AF9 translocations (n = 10). The horizontal line represents the mean for each patient sample group. Data were log2 transformed. (B) Murine genomic regions orthologous to regions of deletion in human patients with ALL. In the bottom panel, the human chromosome map is shown. Blue blocks represent regions of chromosome deletion in ALL patients, and red blocks represent the combined CISs from our murine screen. Genes annotated using Ensembl release 55. (C) Murine genomic regions orthologous to regions of duplication or gain in human patients with ALL. In the bottom panel, the human chromosome map is shown. Blue blocks represent regions of chromosome gain in ALL patients, and red blocks represent the combined CISs from our murine screen. Genes annotated using Ensembl release 55. *Gene in region of gain in human AML that overlapped with a CIS from our murine screen.³²