Model for coagulation signaling to epithelia. In contrast to the activation mechanism in endothelial cells, the activation of PAR-2 signaling on the surface of epithelial cells mediated by TF:FVIIa, FXa, or the ternary TF:FVIIa:FXa complex, can be amplified by the membrane-anchored serine protease matriptase. uPAR, uPA receptor.

Model for coagulation signaling to epithelia. In contrast to the activation mechanism in endothelial cells, the activation of PAR-2 signaling on the surface of epithelial cells mediated by TF:FVIIa, FXa, or the ternary TF:FVIIa:FXa complex, can be amplified by the membrane-anchored serine protease matriptase. uPAR, uPA receptor.

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