Calreticulin at the birth and death of neutrophils. (Left panel) As molecular chaperones in the endoplasmic reticulum, calnexin and calreticulin play a critical role in the productive biosynthesis of myeloperoxidase and other functionally important glycoproteins generated in neutrophil precursors in the bone marrow, with calreticulin tethered in the ER by binding to the KDEL receptor (yellow). (Right panel) At the end of its life, neutrophils rely again on calreticulin bound to the “eat me” signal phosphatidyl serine to promote efferocytosis of apoptotic neutrophils by macrophages. Professional illustration by Somersault18:24.