Roles of eIF4E in BCLs. (A) eIF4E is required for efficient expression of the oncoproteins BCL2, MYC, and BCL6 in aggressive DLBCL. (B) eIF4E inhibition enhances response to the tumor-enriched Hsp90 (TEHsp90) inhibitor PU-H71 by interfering with feedback induction of Hsp70B.