Reversible thrombocytopenia in rhVWF-challenged ADAMTS13 KO mice. Animals were administered 2000 VWF:RCoU/kg BW of rhVWF (●), and platelet counts were determined after 1, 3, and 14 days. A severe thrombocytopenia was noted on day 1 after the challenge. Thrombocytopenia persisted on day 3 but subsided by day 14 compared with untreated ADAMTS13 KO mice (○).