Frequency of detection of 7q and additional abnormalities by SNP-A. (A) Distribution of 7q LOH among the 1458 SNP-A–tested patients with myeloid malignancies, according to World Health Organization disease classification. (B) Number of patients with 7q LOH seen on MC and SNP-A. Lesions were observed in 117 of 1458 and 161 of 1458 patients when using MC and SNP-A, respectively. The additional 7q lesions found by SNP-A included those found in patients with no growth of MC cultures, small deletions affecting balanced translocation boundaries,¹¹  and UPD undetectable by MC.²⁶  (C) Percentage of patients with a sole 7q lesion versus accompanied by other abnormalities as identified by MC and SNP-A. SNP-A indicates single nucleotide polymorphism array;MDS/MPN, myelodysplastic syndrome/myeloproliferative neoplasm; AML, acute myeloid leukemia; MPN myeloproliferative neoplasms; JMML, juvenile myelomonocytic leukemia; FA, Fanconi anemia; UPD, uniparental disomy; MC, metaphase cytogenetics; monosomy 7, deletion of whole chromosome 7; and del(7q), partial deltion involving 7q.